Synthesis of Biopolymers by Condensed Histidine Imide Derivatives with Some Acid Anhydride and Their Crosslink with Acrylonitrite

الملخص

Histidine as known amino acid was converted to its acid chloride [C₁] with thionyl chloride at 0 ^oC, then reacted with ammonia, the corresponding imide-diamine [C₂] was obtained, and then condensed with maleic or methylnadic anhydride. The two novel condensed polymers [C₃, C₄] were obtained with highly conversion percentage and modified to crosslinked polymers [C₅, C₆] with acrylonitrile monomer through vinylic group by free radical polymerization.

The physical properties of all prepared polymers were studied and characterized by ¹H-NMR, FT-IR and UV-visible spectroscopy. The swelling % was calculated.

The new Polymers [C₃, C₄], were synthesized by direct polycondensation to give the new bioactive polymers. The rate of hydrolysis of the prepared polymers was studied in different pH values at 37 ^oC. Howeve, the crosslinked biopolymers [C₅, C₆] indicated much more chemical resistance than [C₃, C₄], and the sustained release was observed as good results in basic medium.