Preparation of Poly (N-4-Antipyrinyl or Procainyl Methyl Nadamic Acids) as Drug Polymers

الملخص

Two new monomers of N-4-antipyrinyl methyl nadamic acid M₁ and N-Procaienyl methyl nadamic acid M₂ were synthesized from reaction of 4-Aminoantipyrine or procaine with methyl nadic anhydride at room temperature with dioxane as a solvent.

The prepared monomers M₁ and M₂ were polymerized free radically with AIBN as initiator to corresponding polyamic acids P₁ and P₂, Which were converted to their sodium salt polymers P₃ and P₄ to enhanced their solubility's in water.

The physical and chemical properties were studied for monomers and polymers, also FT-IR ,¹H-NMR  and UV. Spectroscopy was characterized of M1or M2. The intrinsic viscosity was measured by  Ostwald viscometer at 30 ⁰C  .The swelling %was measured and the controlled release rates of drug polymers were studied in different pH values at 37 ⁰C.