The Activity of 1,3,4 Thiadiazole Derivatives on the Soluble Oils

Abstract

That Thiadiazoles derivative is biologically active as antimicrobial agents in cooling fluids.

Derivatives of 1, 3, 4- thiadiazole have prepared:

• 2-amino-3-[(2-amino-1, 3, 4-thiadiazol-5-yl) dithio] propanoic acid.
• 2-(2-Carbethoxyamino-1, 3, 4-thiadiazol-5-yl)-thio acetic acid.
• [(5-amino-1,3,4-thiadiazol-2-yl) dithio] acetic acid

The synthesized compounds have been used as antimicrobial against the microorganisms which have been found in the cooling fluid of industrial

purposes by using media culture the results showed that the   compounds 1 and 3 are relatively highly active in killing bacteria from the compound 2.

The pH of the cooling fluid samples had been measured after the addition of salt media as well as the inhibitors (1,2,3) the results of pH measurement revealed that the compounds 1,2 and 3 exhibit high activity to inhibit the growth of bacteria.

The turbidity for such media and inhibitors has also been measured and the results indicated that 1,2 and 3 have given low turbidity to inhibit the bacteria or the microorganisms that grow in the cooling fluid.